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Authors: Laurie Bezjian Wallace, DO
Mike O’Callaghan Military Medical Center
Bottom Line Up Front
Utilizing albumin as resuscitative fluid in patients with sepsis demonstrated no difference in all-cause mortality when compared to crystalloid (System of Record ((SOR)) A: meta-analysis of randomized controlled trials [RCTs]). Administration of 300mL of 20% albumin did not significantly lower mortality rates at 28 days or 90 days post-administration (SOR B: single unblinded RCT).
Crystalloid versus colloid fluid resuscitation in septic patients remains a topic of discussion within the critical care community. This article details a meta-analysis and RCT which address the outcomes of utilizing albumin as a resuscitative fluid in patients with sepsis.